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Center for Care Delivery and Outcomes Research

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Frank Lederle

Dr. Lederle, a longtime CCDOR collaborator and colleague, passed away in January 2018.

Frank Lederle, MD was a CCDOR Core Investigator, Director of the Minneapolis VA Center for Epidemiological and Clinical Research (CECR), Physician at the Minneapolis VA and Professor at the University of Minnesota School of Medicine. His research interests included optimizing diagnostic and therapeutic strategies in the primary care of older men with a particular emphasis on the diagnosis, management, and epidemiology of abdominal aortic aneurysms. His research primarily involved large scale clinical trials and technology assessment.

In honor of Dr. Lederle's memory, a charitable fund has been set up to recognize scientific researchers and their work at the VA. Contributions can be made out to the Center for Veterans Research and Education, indicating on the memo line that it is intended for the “Frank Lederle Scientific Paper of the Year Award”.
Mailing address:
Hanna Bloomfield, MD, MPH
Associate Chief of Staff, Research
Minneapolis VA Medical Center
1 Veterans Drive
Minneapolis, MN 55417

To read Dr. Lederle's published essay ‘Terminal’ please click here:

To read Dr. Lederle's final published article in The New England Journal of Medicine please click here:
Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT, Matsumura JS, Huo Z and Johnson GR. Open versus Endovascular Repair of Abdominal Aortic Aneurysm. NEJM 2019; 380(22):2126-2135. doi:10.1056/NEJMoa1715955

Frank Lederle Scientific Paper of the Year Awardees:

Year Awardee Article
2023 Areef Ishani, MD, MS Ishani A, Cushman WC, Leatherman SM, et al. Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. N Engl J Med. 2022 Dec 29; 387(26):2401-2410.
2022 Dimitri Drekonja MD, MS Drekonja DM, Trautner B, Amundson C, Kuskowski M, Johnson JR. Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial. JAMA. 2021 Jul 27;326(4):324-331. doi: 10.1001/jama.2021.9899. PMID: 34313686; PMCID: PMC8317010.
2021 Orly Vardeny, PharD, MS Vardeny O, Kim K, Udell JA, et al. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial. JAMA. 2021;325(1):39–49. doi:10.1001/jama.2020.23649
2019 Philipp Dahm, MD Ilic, D, Djulbegovic, M, Jung, J, Hwang, E C, Zhou, Q, Cleves, A, Agoritsas, T, Dahm, P (2018). Prostate cancer screening with prostate-specific antigen (PSA) test: A systematic review and meta-analysis. BMJ (Online), 362, [k3519].
2018 Erin Krebs, MD Krebs, EE, Gravely, A, Nugent, S, Jensen, AC, DeRonne, B, Goldsmith, ES, Kroenke, K, Bair, MJ, Noorbaloochi, S. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients with Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. JAMA. 2018; 319(9): 872-882