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Center for Care Delivery and Outcomes Research


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Minneapolis Evidence Synthesis Core

Background: The Minneapolis VA is an international leader in conducting and disseminating systematic reviews to assist health care users provide evidence-based high-quality care. Our Minneapolis Evidence Synthesis Core is comprised of multiple clinicians and investigators working collaboratively in different areas. The Minneapolis VA Evidence-based Synthesis and Dissemination Center (MEDIC) is led by Timothy Wilt, MD, MPH, and receives funding through the multiple sources including the VA QUERI Evidence-based Synthesis Program to conduct systematic reviews of the effectiveness and comparative effectiveness and harms of high impact healthcare topics for VA. Our Evidence Review team also conducts evidence reports funded by national medical organizations and used for development of their clinical practice guidelines. We are also partners with the University of Minnesota School of Public Health as the AHRQ-funded Minnesota Evidence-based Practice Center (EPC). Additional evidence synthesis and methods work at the Minneapolis VA is often conducted in collaboration with MEDIC investigators including evidence reviews in urologic diseases in part through Cochrane Urology, Philipp Dahm, MD, MSC, Coordinating Editor (Urology Section). Additionally, Dr. Dahm and Shahnaz Sultan, MD, MSC (GI section) are international leaders in evidence review methodology. They are members of the US Grading of Recommendations Assessment, Development and Evaluation (GRADE) Network that provides national training, mentorship, education and collaboration in systematic reviews and evidence-based health care.

  • Our ESP report on Screening Pelvic Exams provided the evidence base for the American College of Physicians Clinical Practice Guideline on Pelvic Exams. It also has been used by the VA Office of Women’s Health to inform Healthcare practice and policy for Women Veterans. Assessment of its impact in FY15 in the year following its release showed that this guideline has received the most media stories (1,533) and total audience review (188,792,658) and the 2nd most number of web hits (83,000) of any ACP evidence report and clinical guideline.
  • Our ESP report on the Effectiveness and Harms of Pharmacist-Led Chronic Disease Management was published in Annals of Internal Medicine, received positive media coverage and was presented as a VA Cyberseminar.
  • Our MEDIC report on Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia was used by the American Urological Association to develop their 2018 clinical practice guideline.
  • A 2018 Cochrane Urology Rapid Review was used to develop a clinical practice recommendation on PSA screening for Prostate cancer.
  • An AHRQ-EPC review is evaluating long-term efficacy and harms of pharmacologic therapies to prevent osteoporotic fractures. The results are the primary evidence-base for a NIH: Pathways to Prevention Conference to guide future research.
  • Workshops and manuscripts by members of the US GRADE network have served to advance state-of-the art methodology for evidence synthesis and guideline development and expanded the number of individuals trained-in, conducting and using evidence-based health care.

For more information about the VA QUERI Evidence-based Synthesis Program, click below:
For information about the AHRQ Evidence-based Practice Centers, click below:
For information on the US GRADE Network, click below:
For more information about Cochrane Urology, click below: