Minneapolis Evidence Synthesis Core - Center for Care Delivery and Outcomes Research
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Minneapolis Evidence Synthesis Core

Background: The Minneapolis VA is an international leader in conducting and disseminating systematic reviews to assist health care users provide evidence-based high-quality care. Our Minneapolis Evidence Synthesis Core is comprised of multiple clinicians and investigators working collaboratively in different areas. The Minneapolis VA Evidence Synthesis and Dissemination Center (MEDIC) is led by Timothy Wilt, MD, MPH and co-directed by Denise Duan-Porter, MD, PhD. The core receives funding through the multiple sources including the VA Health Services Research and Development Evidence Synthesis Program (ESP) to conduct systematic reviews of the effectiveness and comparative effectiveness and harms of high impact healthcare topics for VA. Our Evidence Review team also conducts evidence reports funded by national medical organizations and used for development of their clinical practice guidelines. We are also partners with the University of Minnesota School of Public Health as the AHRQ-funded Minnesota Evidence-based Practice Center (EPC). Additional evidence synthesis and methods work at the Minneapolis VA is often conducted in collaboration with MEDIC investigators including evidence reviews in urologic diseases in part through Cochrane Urology, Philipp Dahm, MD, MSC, Coordinating Editor (Urology Section). Additionally, Dr. Dahm and Shahnaz Sultan, MD, MSC are international leaders in evidence review methodology. They are members of the US Grading of Recommendations Assessment, Development and Evaluation (GRADE) Network that provides national training, mentorship, education and collaboration in systematic reviews and evidence-based health care.


  • A manuscript from the MEDIC team titled Assessing the Effectiveness of Complex Interventions to Meet the Needs of VA Stakeholders was published in a Medical Caresupplement focused on Evidence Synthesis in a Learning Health Care System.
  • Our ESP reports on Community-based strategies to prevent suicide and Prognostic Factors for Suicide are being used to inform practice and policy within VA, have resulted in peer reviewed publications and presented as VA Cyberseminars.
  • Ongoing ESP reviews include: Implementation of evidence-based psychotherapies for pain; Nursing Home Staffing Models, and Risk Assessment Tools and Prevention Strategies for Diabetic Foot Ulcers.
  • Our VA-ESP is conducting multiple living rapid-reviews on COVID-19 including: remdesivir for adults with COVID-19 (used by the American College of Physicians for their Practice Points guidance statements) and published in Annals of Internal Medicine as well as Post-Acute COVID-19 Major Organ Damage. Both have been presented on multiple occasions to VA clinical and operations leadership.  
  • Our MEDIC reports on Medical and Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia will be used by the American Urological Association to develop their 2020 and 2021 clinical practice guidelines.
  • An AHRQ-EPC review evaluated the comparative effectiveness and harms of clinically localized prostate cancer and is being used by the American Urological Association to develop their clinical practice guidelines.
  • Ongoing AHRQ-EPC reports include: Nutritional Interventions for Cancer Patients with or at risk for Malnutrition and Transitions of Pediatric Care.
  • Multiple MEDIC reports have been used by the American College of Physicians to inform their clinical practice guidelines and published in Annals of Internal Medicine including: Testosterone Therapy for Older Men and High Flow Oxygen for Acute Respiratory Distress Syndrome.  
  • Workshops and manuscripts by members of the US GRADE network, Minnesota AHRQ-EPC and Minneapolis VA-ESP have advanced state-of-the art methodology for evidence synthesis and guideline development and expanded the number of individuals trained-in, conducting and using evidence-based health care.

For more information about the VA Health Services Research and Development Evidence Synthesis Program, click below:
For information about the AHRQ Evidence-based Practice Centers, click below:
For information on the US GRADE Network, click below:
For more information about Cochrane Urology, click below: